|
KMID : 1149220100180020159
|
|
Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 2 p.159 ~ p.166
|
|
|
Acute Toxicity Study of the Hwangryunhaedok-tang Extract in ICR Mice
|
|
Lee Ji-Hye
Eum Hyun-Ae
Chung Tae-Ho
Lee Yoon-Hee
Um Young-Ran
Yim Nam-Hui
Kim Dong-Seon
Ma Jin-Yeul
|
|
|
Abstract
|
|
|
Objective : The objective of this study was to evaluate the single dose oral toxicity of Hwangryundaedok-tang extract in ICR mice.
Methods: 0(control group), 1250, 2500 and 5000 mg/kg of Hwangryundaedok-tang extracts were orally administered to 20 male and 20 female ICR mice. After single oral administration of Hwangryundaedok-tang extract to ICR mice, we observed number of the death, clinical signs, changes of body weights for 14 days. After 14 day of Hwangryundaedok-tang extract administration, all mice were sacrificed and major organs were observed.
Results: Compared with the control group, we could not find any toxic signs in the mortalities, clinical signs, body weight changes, necropsy findings and hematological values in all treated groups(1250, 2500 and 5000 mg/kg).
Conclusions : value of Hwangryundaedok-tang extracts may be over 5000 mg/kg and it may have no side toxic effect to ICR mice.
|
|
|
KEYWORD
|
|
|
Hwangryundaedok-tang, single dose toxicity, Safety, LD50
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|